It is a scenario few could have foreseen after Real won a Liga and Champions League double last term and began this season so convincingly.
Barcelona have one hand firmly on the La Liga title after winning 2-0 at Alaves on Tuesday, leaving them 12 points clear at the top of the table with four games to play.
Messi has been linked with a move away from the Camp Nou at the end of the season after he caused a stir by criticising the club's sporting director Eric Abidal
According to widespread Spanish media reports, Netherlands coach and former Barca defender Ronald Koeman is set to be named as Setien's successor.
Lionel Messi scored twice to earn Barcelona a 2-0 derby win over Espanyol and send them 13 points clear at the top of La Liga on Saturday.
Barca lead the standings on 39 points from 18 games, three clear of second-placed Real Madrid who host Athletic Bilbao on Sunday.
Lionel Messi scored one penalty and missed another as Barcelona beat Real Valladolid 1-0 on Saturday to open up a seven-point lead at the top of La Liga.
Calling his side 'weak', 'inconsistent' and 'very easy to score against', Lionel Messi called for urgent changes
Twenty-three-times Cup winners Athletic Bilbao were dumped out in sensational circumstances by tiny island side SD Formentera, who sneaked a 1-0 win at San Mames with a header by Alvaro Muniz deep in stoppage-time to reach the last 16 for the first time with a 2-1 aggregate victory.
Philippe Coutinho's versatility makes him a great acquisition for Barcelona, coach Ernesto Valverde said on Sunday as the Brazilian made his first public appearance at the Nou Camp following his 142-million-pound ($192.57-million) move from Liverpool.
'It has been good on pitch and off pitch,' Lampard said.
Barcelona coach Luis Enrique is expecting another gruelling game at Athletic Bilbao when the La Liga champions visit San Mames on Sunday.
Santiago Solari got off to the perfect start as Real Madrid's interim coach when his side thrashed Melilla 4-0 in the Copa del Rey on Wednesday.
Messi ran amok at Wembley Stadium, slicing Spurs apart with incisive passes from deep, such as the one that allowed Philippe Coutinho to open the scoring, and was as dangerous as ever in front of goal, firing in the Catalan side's final two goals to end their winless run of three games.
Struggling Rayo win at Valladolid after late penalty save
Lionel Messi became the first player to win 10 La Liga crowns with Barcelona and only the third player from any club to do so.
La Liga leaders Barcelona beat Real Madrid 1-0 to all but knock their rivals out of the title race on Saturday, while second-placed Atletico Madrid stayed seven points behind the Catalans with a 2-0 win at Real Sociedad on Sunday.
'We have to do a lot of self criticism because this is the second time that the same thing has happened to us. We cannot commit the same mistake two years in a row, there are many things we need to consider and think about'
Real will ease the pain by retaining their Champions League title, their only hope of salvaging a disappointing season.
Lionel Messi celebrated his sixth Ballon D'Or award with a brilliant hat-trick as Barcelona moved back top of La Liga with an emphatic 5-2 victory over Real Mallorca.
Betis fans bow to 'extraordinary' Messi after sublime hat-trick Lionel Messi is used to receiving adulation at the Nou Camp but on Sunday he got a rapturous reception from rival supporters for a majestic hat-trick in Barcelona's 4-1 win at Real Betis. Messi opened the scoring with an unstoppable free kick then combined with devastating effect with Luis Suarez to carve Betis open and score a second goal right before halftime. The Argentine saved his best goal for last, completing a victory which took Barca 10 points clear at the top of La Liga with a spectacular first-timed chip from the edge of the area after playing a one-two with Ivan Rakitic. Beaten Betis goalkeeper Pau Lopez looked on in awe while the home supporters, renowned for devotion to their side, rose to their feet, bowed down to Messi and chanted his name. "Even though the opposition concedes goals to Messi they can still enjoy this unbelievable era which he has created, they enjoy it too and today they recognised that," said Barca coach Ernesto Valverde. "It's significant that they gave him this ovation, it's an acknowledgement. Our rivals' supporters have to suffer him but they also appreciate him, because of the player he is. "Leo's performance was extraordinary, he got three goals but he could have got four, that shows you how good he is." Betis coach Quique Setien commended his supporters for their treatment of Messi while saying he felt honoured to work in the same era as the Argentine. "I really like the fact that our supporters showed their appreciation for a great player, today he really made us suffer," Setien said. "It's only fair and it's right to recognise this, our fans behaved in an extraordinary way and I'm very proud of them. I've seen some magnificent players do great things but no-one can match the things Messi has done over the last 12 years. "It's a privilege to have been able to start this era with him and see him in action every weekend." The five-times world player of the year moved on to 39 goals in all competitions this season with two months still left in the campaign. It was Messi's 51st career hat-trick but he could not recall receiving such applause from a rival team's fans. "I cannot remember anything like this before and I'm very grateful for the fans' reaction," Messi said. "I'm very grateful to them and happy for the victory, which was very important."
Real Madrid are on the verge of reaching the King's Cup quarter-finals after winning 3-0 at Numancia on Thursday while holders Barcelona still have work to do after being held to a 1-1 draw at Celta Vigo.
Barcelona's last Champions League triumph came in 2015, and since then they have failed to get beyond the quarter-finals while Real Madrid have monopolised the trophy.
Barcelona have been frighteningly good at home this season, scoring 15 goals in three games at the Nou Camp.
The clinical Argentine Messi now has 11 goals in his last five games in all competitions and with record signing Ousmane Dembele injured and Luis Suarez rested, he put on a sensational show at Camp Nou to extend Barcelona's La Liga lead.
Barcelona fell to a first home defeat in any competition for more than two years
The shock of the season saw Barca suffer their first league loss since going down 2-0 to Malaga on April 8, 2017, ending an incredible, record-breaking sequence that had lasted 43 games.
Marco Asensio followed up his brilliant late goal in Sunday's first leg with a stunning effort from 30 metres in the fourth minute that proved a punishing blow for the Catalans.
The historic rivals will meet again twice in August in the Spanish Super Cup and this International Champions Cup match set the entertainment bar high, with Barcelona maintaining their 100 per cent record in pre-season.
Real play Athletic Bilbao while Barcelona visit Real Sociedad in fixtures that have often proved to be among their hardest away trips over the last decade.
Lionel Messi scored a hat-trick as Barcelona clinched a 25th La Liga title on Sunday after winning 4-2 at Deportivo La Coruna despite throwing away a two-goal lead in a thrilling game which also confirmed Depor's relegation.
Runaway Premier League leaders Manchester City beat champions Chelsea 1-0 at the Etihad Stadium on Sunday to extend their lead to 18 points and leave the London side further adrift from the Champions League qualification spots.
News of all that's transpired on and off the football field
'I've been here 20 years and many times had the opportunity to leave. I don't have to convince you my preference has always been Arsenal'
Coutinho, who arrived from Liverpool for a club record 165 million euros ($185.18 million) in January 2018, has so far shown little to suggest he will be able to compensate for Frenchman Ousmane Dembele's absence against Lyon in the UEFA Champions League tie.
Messi's first act as Barcelona captain was to tell the club's fans at a pre-season friendly in August against Boca Juniors that he and his teammates "will do everything possible so that beautiful and desired cup returns here to the Nou Camp".
With the Catalans shorn of three of their top forwards, all eyes will be on Griezmann in his first appearance at the Camp Nou since his 120-million-euro ($133 million) move from Atletico Madrid, and not least because Barca need a win to kickstart their season.
Real coach Julen Lopetegui has come in for fierce criticism this season, having presided over a run of five games without a win -- the team going eight hours and one minute without scoring -- before Tuesday's unconvincing 2-1 triumph over Viktoria Plzen that saw the team whistled off the pitch by their own fans.
Here are five talking points from the weekend in La Liga:
Barca, who were without injured talisman Lionel Messi, started on the back foot and fell behind when Nabil Fekir netted with a sublime angled strike in the 15th minute. Griezmann, who joined Barca last month from rivals Atletico Madrid, scored four minutes before halftime to level the scores.